Three plus signs of Helicobacter pylori generally means positive for Helicobacter pylori, which means Helicobacter pylori infection. H. pylori is a conditionally pathogenic bacterium that can parasitize the gastric mucosal tissues, and can cause a series of gastrointestinal diseases in patients after infection, such as chronic gastritis, erosive gastritis, gastric ulcers, duodenal ulcers and so on. Most infected people have no obvious specific symptoms, some patients may experience abdominal pain, bloating, loss of appetite, acid reflux, nausea and other symptoms. It is recommended that patients with Helicobacter pylori infection improve gastroscopy to clarify the presence or absence of lesions. Infected people under the guidance of the doctor to use quadruple drugs for sterilization treatment, usually a proton pump inhibitor such as omeprazole, a bismuth such as bismuth pectin, two antibiotics such as amoxicillin, metronidazole and so on into the treatment. Patients need to strictly follow the doctor’s prescription medication. It is recommended to actively cooperate with the doctor’s treatment, develop good living habits and dietary habits, pay attention to monitoring the condition and regular review.