Acne is a chronic inflammation of the sebaceous glands of hair follicles caused by a variety of factors. The main clinical manifestations are acne (blackheads, whiteheads), papules, pustules, nodules, cysts and scarring. It occurs on the face, back, chest and other areas rich in sebaceous glands. Modern research suggests that the cause of the disease is mainly related to hyperfunction of androgenic kinins and sebaceous glands, abnormal hair follicle sebum, the role of microorganisms in the hair follicle sebaceous units, and inflammatory reactions. In the course of dermatology clinical consultations, it was found that post-pubertal acne is more prevalent in women over 30 years of age. Some scholars believe that due to the disorder of androgen metabolism in the peripheral skin tissues of these patients, estradiol decreases and serum testosterone levels increase, which leads to phenomena such as late-onset acne and aggravation of premenstrual symptoms, and is closely related to the patient’s psychological factors. These female patients are often associated with sleep disorders, emotional instability, poorer emotional stability, and more intense reactions to life events. Therefore, experts believe that psychological factors are related to post-pubertal acne in women, and that chronic, long-term mental stress may be one of the important triggers. When people are under mental stress from all sides, depression, anxiety and other emotional changes will pass through the “cerebral cortex – limbic system” emotional circuit, sending nerve impulses to the hypothalamus – pituitary – gonadal axis or adrenal axis, resulting in an increase in androgens. In addition, the sebaceous glands themselves have increased sensitivity to androgens. The sebaceous gland cells have the highest distribution of androgen receptors and have a special affinity for androgens in the circulating blood. Of course, due to individual differences in genetics, the distribution and number of androgen receptors in sebaceous gland cells are different, and the affinity of the receptors for androgens is also different. As a result, the onset of acne appears to vary in severity. The onset of acne in young and middle-aged women is causally related to the psychological factors of the person. Chronic, long-term mental and emotional factors lead to the occurrence of acne, and in turn the onset of acne has an impact on the mental health of these patients, especially on their quality of life, which further aggravates their anxiety, depression, and other mental, emotional, and psychological problems. As a result, the prevention and treatment of acne is no longer limited to the biomedical model, but has gradually developed into a “biopsychosocial medicine” model. Clinically, for patients with obvious psychological factors, psychological counseling should be used to improve the effectiveness of treatment and inhibit recurrence. Surviving in society, the pressure from life, work and other aspects is inevitable. We should learn to soothe them through communication, talking, exercise, excursions, and dietary modifications, which will help prevent the occurrence of acne. After the occurrence of acne, the first thing to do is to carry out the necessary Chinese and Western drug treatment, internal and external use, and at the same time need to actively adjust the mentality, so as not to be impatient, not to be depressed, not to be anxious, to understand the treatment and healing process of the disease, and to cooperate with the doctor’s medication, will play a positive role in the cure of the disease.