After Mycobacterium tuberculosis is resistant to rifampicin, drug sensitivity test should be done in time, and other anti-tuberculosis drugs such as pyrazinamide, isoniazid, kanamycin should be switched according to the results of drug sensitivity. Mycobacterium tuberculosis is the pathogen that causes tuberculosis in human beings, and it is a kind of aerobic bacteria with strong resistance. Currently, anti-tuberculosis drugs are categorized into first-line drugs such as isoniazid, rifampicin, pyrazinamide, etc. and second-line drugs such as capreomycin, quinolones (e.g., levofloxacin, etc.), aminoglycosides (e.g., amikacin, etc.). Clinically, Mycobacterium tuberculosis is prone to drug resistance, mostly due to inappropriate regimen of treatment or irregularity of medication. If you find resistance to rifampicin, you need to do drug sensitivity test in the hospital in time, and according to the test results, choose the appropriate anti-tuberculosis drugs to continue treatment. Rifampicin use may have nausea, vomiting and other adverse effects, for liver insufficiency, biliary obstruction of people can not be used, use should pay attention to avoid drinking alcohol. The treatment of tuberculosis must be in accordance with the doctor’s program of rational use of drugs, avoid changing on their own.