Creatinine 165μmol/L is generally not serious if it belongs to physiologic increase; if it belongs to the elevation caused by acute kidney injury in the pathologic increase, it is also generally not serious, and if it is a chronic elevation, it is more serious. 1. Physiological increase: generally not serious and no special treatment is needed. For example, after strenuous exercise, eating a large amount of meat food, too much emotional stress and anxiety, etc., may lead to high creatinine, but physiological factors caused by high creatinine will not affect renal function and renal excretion, so it is not serious, but it is still recommended to review regularly to assess renal function. 2. Pathological increase (1) If creatinine 165μmol/L is pathologically elevated, the excretion of renal function has been changed. If the increase is acute, such as diarrhea, infection and other transient increase in creatinine, after removing the cause of the disease and symptomatic treatment, it can usually be recovered, so it is not serious. (2) If the elevation of creatinine is chronic, i.e. chronic renal failure, it will be more serious, and if it is not treated in time, further aggravation of the condition will develop into uremia. If creatinine index is high, it is recommended to go to the hospital regularly to check the renal function, to know the damage of renal function, and once abnormalities are found, you should strictly follow the doctor’s instructions to carry out regular treatment.