Helicobacter pylori infection has 2 + serious or not, need to be discussed separately in the context of atrophic gastritis, peptic ulcer, immune deficiency, etc. Generally speaking, the first two serious, the latter is not serious. 1. Atrophic gastritis: Helicobacter pylori has some influence on the formation of atrophic gastritis. When atrophic gastritis with Helicobacter pylori infection with 2+, atrophic gastritis is a common precancerous disease that needs to be treated in time, so atrophic gastritis with Helicobacter pylori infection with 2+ is serious. 2. Peptic ulcer: If peptic ulcer is accompanied by Helicobacter pylori infection with 2+, the presence of Helicobacter pylori will prolong or even aggravate the repair of the ulcer surface, so it is serious and needs timely treatment. 3. Immunity decline: normal people do not have gastric diseases, but over a period of time too tired and other reasons lead to immunity decline, and then due to dietary habits, Helicobacter pylori bacteria may be infected in the stomach and have 2 +. This condition can be cured only with appropriate treatment and is not serious. H. pylori infection with 2+ test results alone can not accurately determine the cause and severity of the disease, but also need to be combined with the characteristics of the medical history, other test results to make an accurate judgment, it is recommended to clarify the cause of the disease under the guidance of a doctor, and then give standardized treatment.