High bile acid is commonly found in hepatobiliary diseases, such as viral hepatitis, cirrhosis, and liver cancer, which can be treated with medication and surgery according to one’s condition, and commonly used medications include nucleoside analogs or interferon. Increased bile acids are common in hepatobiliary diseases, if it is due to viral hepatitis caused by increased bile acids, need to actively treat the primary disease, commonly used antiviral drugs, such as entecavir or tenofovir antiviral therapy, but also can use α-2b interferon. If it is caused by alcoholic cirrhosis, alcohol consumption should be restricted, and drugs should be used for treatment, such as Metadoxine, which can speed up the clearance rate from the serum; S-adenosylmethionine, which can relieve the symptoms and improve the serum index; and glucocorticosteroids, such as Prednisone, can also be used. Surgery is feasible for patients with hepatocellular carcinoma, with adjuvant chemotherapy and radiotherapy. Increased bile acid can also be seen in biliary obstruction, cholestasis during pregnancy, etc. One should consult the doctor in time and treat under the doctor’s guidance, pay attention to diet and hygiene in daily life, quit smoking and limit alcohol, pay attention to living habits.