(Disclaimer: This article is only for scientific purposes, in order to protect the patient’s privacy, the relevant information in the following content has been processed) Abstract: The patient was diagnosed with duodenal ulcer 2 months ago, and conservative treatment was given to the patient, but the patient failed to take the medication on time, and came to the clinic because of the sudden onset of epigastric slashing pain in the middle of the night, and the examination showed abdominal compression pain, rebound pain was obvious, and the abdominal stadiograph showed that there was free gas in the subdiaphragm of both diaphragms, and the results suggested that peptic perforation was found in the abdomen. The results suggested perforation of the digestive tract, the patient was given laparoscopic exploration under general anesthesia, postoperative treatment with medication, the patient’s prognosis was good, the patient was discharged with good recovery, and there was no recurrence in the follow-up. 【Basic information】 Female, 25 years old 【Disease type】 Duodenal perforation 【Hospital visit】 The First Affiliated Hospital of Chongqing Medical University 【Date of visit】 September 2021 【Treatment plan】 Surgery (laparoscopic repair of duodenal perforation) + oral medication (omeprazole enteric-coated capsule) + intravenous infusion (cefotaxime sodium sulbactam sodium for injection) 【Treatment cycle】 Hospitalization for 5 days. Postoperative follow-up 【Treatment effect】 Patient’s prognosis is good, no recurrence on follow-up I. Initial interview Patient’s life is irregular, 2 months ago recurrent epigastric pain, most of which occurs on an empty stomach or at night, and can be relieved by eating, and in the middle of which the patient went to the outpatient clinic for treatment once, and at that time was diagnosed as a duodenal ulcer, and prescribed medication for conservative treatment, and instructed to follow up on a regular basis. However, due to the patient’s busy work schedule, the previously prescribed medication was not taken on time, and did not take the time to come back to the clinic. 7 days ago, the patient suddenly suffered from a cutting pain in the upper abdomen in the middle of the night, and went to the emergency room of our hospital, and was admitted to the hospital with unexplained abdominal pain. Second, the treatment process for the patient to carry out physical examination, the results show that the whole abdomen pressure pain, rebound pain obvious, abdominal standing film shows double diaphragm under the free gas, CT results of the upper abdomen suggests that the digestive tract perforation, and the patient’s abdominal cavity has a small amount of fluid, the diagnosis of the upper gastrointestinal tract perforation. Examination of blood routine showed increased white blood cell count, suggesting inflammation. After clarifying that the patient had no obvious contraindications, laparoscopic exploration was performed under general anesthesia, and perforation of the duodenal bulb was seen, which is the most common site of duodenal ulcers, and the tissue at the perforation was pale and hard, and yellow pus was seen at the lower edge of the liver, the right iliac fossa, and the pelvis, and the ulcers were taken and sent to pathological biopsy, and then perforation repair was carried out immediately afterward. After the operation, the patient was given omeprazole enteric capsule to reduce gastric acid stimulation, and cefotaxime sodium sulbactam sodium for injection to fight infection, and the patient was discharged from the hospital with good recovery. After the operation, the patient’s abdominal pain was significantly relieved without abdominal distension, diarrhea, chills, fever and other discomforts, and the surgical opening healed well without bleeding, redness, swelling, oozing and other abnormalities. After being able to eat after surgery, the patient could eat easily digestible food without gastrointestinal side effects. The patient maintained good work and rest habits during hospitalization and had a good mental state. After 5 days of hospitalization, the patient recovered well and was successfully discharged from the hospital. After discharge, the patient actively complied with the doctor’s instructions for treatment, and the current prognosis is very satisfactory. After active surgical treatment and postoperative anti-infection treatment, the patient recovered well without complications. Seeing the patient’s good treatment results, I am also sincerely happy for him. However, for the sake of the patient’s health in the future, the patient should pay attention to the regularity of life after discharge from the hospital, less stay up late, relax the mood, and at the same time, should pay attention to the regularity of eating, light diet, avoiding spicy, stimulating, greasy food. Patients should have regular follow-up, if any discomfort occurs, must consult the doctor in time, for peptic ulcer patients, regular follow-up gastroscopy is very important. Fifth, personal perception duodenal ulcer can occur at any age, clinically very common in young and middle-aged patients, mostly due to usually do not pay attention to regular work and rest and regular diet, so usually pay attention to regular work and rest in life and diet, maintain a good diet, can be effective in preventing the occurrence of such diseases. The patient in this article duodenal ulcer has an acute onset of disease, and not timely follow-up after the consultation, only secondary to the duodenal perforation, but the good thing is that the patient after surgical treatment, the prognosis of the situation is better. However, this incident tells us that if there is a peptic ulcer, it should be treated as early as possible and regularly reviewed to avoid further development.