Domestic targeted drugs for lung adenocarcinoma mainly include EGFR mutation drugs Eketinib and Amedinib, and anti-vascular targeted drugs Apatinib and Anrotinib. Lung adenocarcinoma is a relatively common type of lung cancer. For patients who cannot undergo surgery, targeted drug therapy can achieve better therapeutic effect than traditional radiotherapy, and often the adverse effects are relatively mild, which can be tolerated by most patients. Domestic targeted drugs have achieved better results in recent years, which can have the same therapeutic effect as imported drugs, and the price is also lower, and most of them are within the scope of reimbursement of medical insurance, which eases the medical burden of patients. In the application of targeted drugs should be applied under the guidance of the doctor, pay attention to review whether there are side effects and how effective the treatment.