Spots on both sides of the cheeks of the face are usually caused by freckles, chloasma, seborrheic keratosis and other diseases. 1. Freckles: mostly related to heredity, patients will have dotted, ovoid or irregular light brown spots on both cheeks, nose, neck and other exposed parts of the face. The lesions are more obvious in summer due to strong sunlight, while they are not obvious in winter. 2. Melasma: also known as butterfly spot, pregnancy spot, etc. The cause of the disease has not been completely clarified, and it is related to heredity, ultraviolet irradiation, hormone level changes, etc. The patients will have light yellow-brown, dark brown spots on both sides of the cheeks, forehead, jaw, and other sunlight-exposed parts of the face and they will have a symmetrical distribution, and the patients do not have any self-conscious symptom. 3. Seborrheic keratosis: the etiology and pathogenesis of this disease is not completely clear, may be related to age, heredity, sun exposure, air infection and other factors. Patients face cheeks on both sides, the back of the hands, trunk and other parts of the face will continue to press a after more than one flat light brown spots, lesions are generally less than 1cm, occasionally more than 5cm in diameter, in addition, lesions are generally higher or slightly higher than the skin surface. In addition, there are many reasons that can cause long spots on both sides of the cheeks of the face, and it is recommended that patients go to regular hospitals in time to receive treatment as early as possible after the cause is clarified.