Squatting ankle pain may be caused by ankle sprain, ankle fracture, synovitis and other conditions, patients need to follow the doctor’s instructions for medication, surgical treatment and so on. 1. Ankle sprain: Usually patients can follow the doctor’s instructions to use ibuprofen, indomethacin and other non-steroidal anti-inflammatory drugs to reduce pain and inflammation, while some patients can also use celecoxib, nimesulide and other COX-2 inhibitors. Patients also need to rest more after the injury, local ice packs, and compression bandage, appropriate elevation of the ankle joint, can also relieve swelling. If conservative treatment is ineffective, arthroscopic repair is also needed. 2. Ankle fracture: Usually, the patient needs to be manipulated under the premise of full anesthesia, and if the condition is serious, the patient needs to be reset by surgery such as incision and internal fixation. After the reset, the patient should be immobilized in plaster for 6~8 weeks and take non-steroidal anti-inflammatory drugs such as Celecoxib to relieve the pain. 3. Synovitis: patients can also take the above non-steroidal anti-inflammatory drugs to relieve pain symptoms, and can also be used topically with diclofenac diethylamine emulsion and other anti-inflammatory and analgesic treatment. In the case of acute suppurative bursitis, antibiotics such as ampicillin and gentamicin should be used. If conservative treatment is ineffective, arthroscopic debridement is also needed. It is recommended that patients with symptoms of squatting ankle pain, according to their own situation, timely find out the cause of the disease, and follow the doctor’s instructions reasonable treatment, do not blindly use drugs.