Psoriasis is a chronic, relapsing inflammatory disease that so far has not been completely curable. But happily, with the continuous understanding of its pathogenesis and the development of new drugs, it has been possible to achieve the best results of rapid onset of action, comprehensive clearance and long-term stability. Since 2004, when the first biologic agent for psoriasis treatment, tumor necrosis factor alpha antagonist (etanercept, Ixep), was marketed in the United States, new biologics have been introduced, such as its counterparts infliximab (classical) and adalimumab (Xumel), which have been used in China for many years and have exerted very good effects in clinical practice. In 2019, there are even new targeted therapeutics, such as interleukin 12/23 antagonist (Usnu), interleukin 17a antagonist secukizumab (Cosentin) and echizumab (Topaz), as well as guselizumab (Tenoia), which have entered the Chinese market, bringing miraculous results for the treatment of moderate-to-severe psoriasis. People define 2019 as the first year of biologics for psoriasis treatment. At the request of patients, we are here to answer questions related to biologics. Q: Is it convenient to administer biologics? Is it possible to self-administer medication at home? A: Most biological agents are administered by subcutaneous injection and have been prepared as pre-filled needles or self-administered needles, which are very convenient and can be injected by themselves. These drugs are different from the traditional drug administration method, and will usually be injected subcutaneously every 1-2 weeks during the induction period, and after the induction period, they can be administered once every 1-3 months. Q: How long does it take to get results with biologics? A: Most of the drugs will take effect in about 2 weeks, and the skin lesions can be improved by more than 50%, and some patients will be improved by more than 75%. Q: I am under treatment with biologics, but due to an epidemic or for some reason, I was forced to interrupt treatment after the first injection, and it has been 2 months since. Do I need to restart it? A: Yes, you need to start the induction period from the first injection. Q: Is the biological agent safe? Are there any side effects? A: Biologics are very safe and have fewer side effects than traditional therapeutic drugs such as Avelox, methotrexate and cyclosporine. There is a large sample of data from overseas for up to 5 years showing that biologics are very safe and no serious adverse events have occurred. Q: I am a woman with psoriasis, will the use of biologics affect my fertility? If I want to prepare for pregnancy, do I need to stop using biologics? A: Biologics are a relatively safe drug. Most biologic guidelines state that for women of childbearing potential, effective contraception is required during the use of biologics and for 6 months after the end of treatment. For male patients, effective contraception is recommended during the use of the drug and it is safer to resume pregnancy preparation three months after discontinuing the biologic. Q: After the use of biological agents, psoriasis has been completely cured, can the dosage be reduced or stopped at this time? A: Psoriasis is a disease that cannot be completely cured and requires long-term maintenance treatment. Therefore, when using biological agents, even though psoriasis has been fully controlled, it is recommended to maintain the treatment if the economic condition allows. Q: Are there any contraindications to biological agents? A: Before applying biologics, one needs to be screened for tuberculosis, hepatitis B and C, oncology, AIDS and autoimmune diseases.