Children’s fever and lack of energy may be caused by pneumonia, or it may be due to hand, foot and mouth disease. The cause of the illness needs to be clarified and targeted treatment should be given at the same time as antipyretic treatment. Children with fever need to choose the appropriate antipyretic method according to the degree of elevated body temperature, such as physical hypothermia, oral medication. For children with body temperature <38.5 ℃ can use warm water on the child's forehead, reduce the wearing of clothing and other physical methods to reduce temperature; for children with body temperature ≥38.5 ℃ need to use ibuprofen, acetaminophen and other drugs under the guidance of the doctor for antipyretic treatment. In the antipyretic treatment at the same time need to pay attention to clarify the cause of the disease, and give targeted treatment. If it is caused by pneumonia, we should strengthen the nursing care, ensure sufficient rest, maintain indoor air circulation and a certain degree of temperature and humidity; caused by bacterial infections need to be based on the results of drug sensitivity tests to use sensitive antibiotics, such as ceftriaxone, penicillin, etc.; viral infections are generally no special medication; influenza virus infections with oseltamivir treatment. Hand, foot and mouth disease is an acute febrile rash disease caused by enterovirus. The disease can also cause children to have fever and lack of energy. It is necessary to pay attention to appropriate rest, light diet, good oral and skin care, and keep the airway open. Oxygen should be administered if necessary, and methylprednisolone, dexamethasone, and immunoglobulin injections should be used as prescribed by the doctor. All of the above drugs need to be used under the guidance of a doctor, avoid self-medication. There are many other causes of fever and lack of energy in babies, and it is recommended to consult a doctor in time to be evaluated and treated by a specialist.