Moodiness the day after drinking is clinically mainly due to the action of alcohol on the body, which causes the body to have a bad experience, so the patient may wake up the next day with physical discomfort, and then feel remorseful for having drunk too much alcohol yesterday, thus producing a poor mood and a situation of moodiness. Therefore, the main clinical effect of alcohol as a neuroleptic agent is the emotional reaction to heavy drinking. At the same time, when alcohol is first consumed, it has a certain euphoric effect that stimulates the excitement of the brain, so that the patient begins to have a pleasant floating feeling, and as the dose of drinking increases, its inhibitory effect continues to manifest, so it leads to changes in gastrointestinal function, the brain, and the cardiovascular system. Dizziness, headache, gastrointestinal discomfort, panic and palpitations, rapid heartbeat, and profuse sweating are some of the physical manifestations associated with alcohol consumption. It is also important to evaluate this somatic discomfort experience after drinking alcohol, especially the emotional depression caused by remorse over yesterday’s excessive drinking.