Non-invasive DNA is not always accurate in advanced maternal age, and prenatal diagnosis is also recommended on a case-by-case basis as prescribed by the doctor. Advanced maternal age is defined as age ≥35 years, belonging to the high-risk group, the risk of fetal birth defects is increased, especially chromosomal disorders, and prenatal diagnosis is needed to clearly exclude the risk of fetal developmental abnormalities. Non-invasive DNA is a prenatal screening method with a high detection rate of chromosomal disorders, so prenatal non-invasive DNA testing is recommended for women of advanced maternal age. Senior women also need to strictly follow the doctor’s instructions on time, strengthen the management of pregnancy, standardized obstetric examination can be timely detection of pregnancy complications or complications, as well as found fetal abnormalities, and timely treatment, but also to assess maternal and fetal safety, to determine the timing and mode of delivery, in order to ensure that the safety of mothers and infants during pregnancy.