Symptoms of maternal and fetal blood group incompatibility are mostly not serious for ABO blood group incompatibility as well as Rh blood group incompatibility of the first child, and Rh blood group incompatibility of the second child is relatively serious. When the effect is serious, abnormal symptoms during pregnancy such as abdominal pain, bleeding, cessation of fetal movement, miscarriage, etc.; abnormal symptoms in newborns include jaundice, anemia, hepatosplenomegaly, lethargy, low response, convulsions, etc. 1. Abnormal symptoms during pregnancy: pregnant women and fetus blood type incompatibility, if it is more serious pregnant women may experience symptoms such as abdominal pain, bleeding, cessation of fetal movement, expulsion of embryonic tissue or fetus from the body. 2. Abnormal symptoms of the newborn after delivery: including jaundice, anemia, hepatosplenomegaly, and complications can occur in severe cases. (1) Jaundice: in case of blood group incompatibility between the pregnant woman and the fetus, most of the children with ABO blood group incompatibility will develop jaundice in 2~3 days after delivery, while those with Rh blood group incompatibility will develop jaundice in 24 hours after delivery, which will worsen rapidly. (2) Anemia: It mainly occurs in children with Rh blood group incompatibility, who have severe anemia or heart failure after birth, and some of them have advanced anemia after 3-6 weeks after delivery. (3) Liver and spleen enlargement: Children with Rh blood group incompatibility often have different degrees of liver and spleen enlargement. (4) Complications: Serious cases of blood group incompatibility between pregnant women and fetuses can cause bilirubin encephalopathy, bilirubin-induced neurological dysfunction and other complications, which can be manifested as lethargy, low response, convulsions, cognitive function abnormalities, hearing impairment and so on. When there is a suspicion of blood group incompatibility between a pregnant woman and her fetus, it is necessary to go to the hospital for examination in time to avoid delaying the condition.