The small grains on the neck are thought to be caused by human papilloma virus infection, and there are several ways to remove them: 1, physical methods, mainly laser or microwave ablation, for relatively small grains, is to use laser or microwave cauterization of small grains on the skin, and use the instant high temperature to kill the virus in it. This method is clean, thorough and fast, but the cauterized wound is prone to infection, so local antibiotics are needed to prevent infection. 2, mechanical methods, represented by the hanging wire therapy, for relatively large, narrow base of the slender grains, is the use of sterile thin wire tied to the base of the grains, so that the ischemia, necrosis and natural fall off. This method is time-consuming, but the trauma is small, because it can not remove the virus, so it needs to be combined with oral antiviral drug treatment. 3, chemical methods, the use of chemical corrosive agents to corrode the small granules to make them fall off, because of the side effects of the method, now less used.