At present, there is no high-quality research to prove that BCG is available for the treatment of prostate cancer, and the domestic guidelines and consensus have not taken it as the recommended treatment. BCG can increase tumor antigenicity, activate macrophages, which is beneficial to the body’s anti-tumor immune response effect, and can also prolong the effect of tumor drugs by inhibiting drug metabolizing enzymes, and is currently used for bladder perfusion treatment of bladder cancer patients after surgery. However, there is no clear, high-quality clinical research and basic research to confirm the value of BCG in the treatment of prostate cancer. And it has not yet been used as a recommended treatment option in national guidelines and expert consensus. In conclusion, there is no high-quality evidence that BCG can be used in the treatment of prostate cancer. If prostate cancer is suspected or diagnosed, it is recommended to go to a regular hospital for a comprehensive assessment of the condition, follow the doctor’s instructions, and choose the appropriate treatment plan to avoid delaying the condition. Please strictly follow the doctor’s prescription for medication, and do not use medication on your own.