Patient: Patient female, 58 years old, suffered from upper gastrointestinal bleeding in 1993, half a month after the blood transfusion got viral hepatitis, after hospitalization and healing, these years have been very good. 2010 July 21 discomfort, slight pain in the liver, to the local specialist hospital examination, glutathione transaminase 48, hepatitis C virus RNA quantification reached more than 17,000, at home to eat half a month of Yihelian and hepatocyte, August 2 The virus is back within the normal range and the transaminases are also back to normal, but many doctors say that it is impossible to reduce the RNA of this virus, which makes people puzzled: 1, is the patient’s hepatitis C infectious and does it need to be isolated? 2. Will the patient’s RNA virus quantification be reduced by these two drug treatments? 3. Is there any other way to control hepatitis C other than interferon treatment? 4.What do patients need to pay attention to? Feng Bo, Institute of Liver Diseases, Peking University Hospital: 1. HCV is mainly transmitted through blood, such as through blood transfusion and blood products, and through broken skin and mucous membranes. Secondly, it can be transmitted through sexual contact and mother-to-child transmission. The HCV is generally not transmitted by kissing, hugging, sneezing, coughing, food, drinking, sharing utensils and water glasses, no skin breakage and other non-blood exposed contacts. The two drugs you are taking are liver-protective and enzyme-lowering, not anti-viral. 3, interferon (IFN) alpha is an effective anti-HCV drug. The combination of pegylated interferon alpha and ribavirin is currently the most effective antiviral treatment program, followed by the combination of common interferon and ribavirin therapy. Oral anti-hepatitis C virus drugs are still in the process of clinical trials, but according to current data, all need to be used in combination with interferon. 4. Regarding the diagnosis of hepatitis C, it is recommended to recheck the HCV RNA and also pay attention to the anti-HCV titer and check the abdominal ultrasound. If the diagnosis is clear and there are no contraindications to interferon application, antiviral therapy should be considered.