A positive leukocyte esterase is usually indicative of the presence of infection localized to the sample collected. Leukocyte esterase is a specific enzyme found in human neutrophils and is used clinically to detect the presence of neutrophils in a sample. A positive test for leukocyte esterase indicates the presence of neutrophils in the sample, usually the patient’s urine or vaginal secretions. Neutrophils are inflammatory cells that, when present, are usually indicative of a bacterial infection in the urethra or vagina, and are more commonly associated with urethritis, cystitis, pyelonephritis, nephritis, and bacterial vaginitis. However, sometimes poor local hygiene may also result in high leukocyte esterase. The doctor will determine whether treatment is needed according to the specific situation. In general, you should pay attention to personal hygiene, wash the vulva often with water, and avoid unclean sex, etc.