The main hazard of liver puncture biopsy is that it is an invasive procedure, which may cause bleeding, accidental injury to other organs and other hazards. 1. Bleeding: As a tissue and organ with rich blood supply, the liver is commonly harmed in the process of puncture, which causes bleeding. For example, bleeding at the puncture point of the liver, bleeding in the abdominal cavity, even causing liver injury, biliary fistula, intrahepatic arteriovenous fistula, intrahepatic infection, abdominal infection, and puncture to the lungs causing pneumothorax. 2. Accidental injury to other organs: for example, puncture to the organs next to the liver (such as the colon), while liver puncture is also prone to local skin or subcutaneous tissue injury, both in the puncture process, you can see the subcutaneous hematoma, or intra-tissue hematoma and other bleeding problems. 3. In addition, if the puncture is for tumors, there is a possibility that the puncture process for malignant tumors may lead to metastasis of the tumor through the needle tract. However, at present, through preoperative testing, testing of coagulation function, intraoperative ultrasound guidance, and postoperative local pressure bandage, liver puncture biopsy is relatively a safe operation, which has a high degree of safety and a low probability of risk occurrence.