Fever with thrombocytopenia syndrome is an acute infectious disease caused by a novel bunyavirus, the main manifestation of which is thrombocytopenia. There is no specific treatment, but the main treatment is symptomatic support. Patients should rest in bed, eat a liquid or semi-liquid diet, and drink warm water and warm juices. Patients who are unable to eat or are seriously ill should be given caloric supplements to ensure water-electrolyte and acid-base balance. Special attention should be given to hyponatremic patients to supplement, and those with hyperthermia can do physical cooling and, if necessary, use drugs to reduce fever. If there is significant bleeding or significantly lower platelets, for example, below 30×10^9/L, plasma and platelets can be transfused. In cases of severely low neutrophils such as below 1×10/L, in such cases granulocyte colony-stimulating factor is recommended. In addition, ribavirin can be used appropriately to have certain efficacy in antiviral, and if there is secondary bacterial infection and fungal infection should choose sensitive antibiotic treatment, while paying attention to the underlying disease. Also pay attention to the treatment of the underlying disease. There is no evidence to prove the therapeutic effect of glucocorticoids and they should be used with caution.