Many patients who are first diagnosed with Parkinson’s disease may wonder why they suddenly get Parkinson’s disease. Some patients ask for examination in the hope of checking out where the problem is, and some patients have already been examined in other hospitals, or have regular physical examination every year, and found that the report is normal, and some patients are found to have cerebral infarction, and there are quite a number of patients treated for cerebral infarction, with no improvement. Research has found that Parkinson’s disease is not a sudden, but early signs, just limb tremor, slow movement, stiffness and other typical symptoms are not obvious, patients do not know. It was found that Parkinson’s disease is due to the reduction of nigrostriatal neurons in the midbrain, resulting in a reduction in the amount of a neurotransmitter called dopamine, which is unable to maintain the normal functioning of the body, resulting in a series of symptoms of abnormal limb movements. After further research, it was found that when the symptoms of Parkinson’s disease appeared, the number of substantia nigra neurons had decreased to more than 80%, which is why Parkinson’s disease is called a “silent killer”, with an insidious onset of the disease and a slow progression. So why is the nigrostriatal neurons slowly decreasing? Research has found that it is related to the following factors. 1, age factors: Parkinson’s disease patient age, middle-aged and old people, indicating that with the increase in age, the nigrostriatal neurons continue to decrease, resulting in a continuous decrease in the number of dopamine, the level of regulation declined, and nigrostriatal neurons decrease faster than the normal rate of aging. Therefore, age is also considered to be the cause of Parkinson’s disease. 2.Genetic factors: research and investigation found that there is a family history of the disease is significantly higher than the general population, but also found that some genetic variants of genes, genetic factors account for about 10%. 3, environmental factors: mainly environmental toxins, such as carbon monoxide poisoning, long-term exposure to pesticides (insecticides, etc.), or other toxic gases, heavy metals, toxic chemicals, etc., the brain’s nervous system has damage, may lead to Parkinson’s syndrome. 4, drug factors: studies have found that long-term use of some anti-psychotics and certain drugs to inhibit high blood pressure, the probability of developing Parkinson’s syndrome is high. 5.Disease factors: such as traumatic brain injury, cerebral arteriosclerosis, multi-system atrophy, depression, etc., resulting in patients with neurological damage or neurological disorders, may trigger the occurrence of Parkinson’s disease. All of the above factors may be involved in the occurrence of primary Parkinson’s disease and Parkinson’s syndrome, so Parkinson’s disease is not suddenly acquired, but undergoes a long process and appears at a certain age. With the knowledge of these involved factors, preventive measures can be taken in advance. If the symptoms of Parkinson’s disease have already appeared, timely consultation and treatment, through reasonable medication and surgical treatment of brain pacemaker, comprehensively improve the symptoms, so that patients can live on their own and improve the quality of life.