Calcium loss can produce pain and hypocalcemia, as follows: First, pain: Patients with calcium loss will have symptoms of generalized skeletal pain, accompanied by muscle weakness. The pain will persist, affecting the patient’s normal life and work, even unable to participate in sports, and the strength of the bone will be significantly reduced, making it easy for pathological fractures to occur under the action of external forces. Second, hypocalcemia: Calcium loss can also cause hypocalcemia, which can lead to increased nerve and muscle excitability. Patients can have the symptoms of perioral numbness and cramps at the end of the limbs, which are more serious at night, while patients will have persistent pain symptoms in the muscles of the limbs. After calcium loss, patients mainly produce the above symptoms. Early diagnosis and early treatment can replenish calcium loss and prevent patients from developing the above clinical symptoms. It is also necessary to strengthen physical exercise in normal life to promote the recovery of muscle strength, as well as balanced nutrition and calcium supplementation.