Wake up with neck pain, may be related to physiological factors, may also be pillow, cervical spondylosis and other factors. 1. Physiological factors: if you do not pay attention to warmth during sleep, resulting in prolonged cold stimulation of the neck, or sleeping in an inappropriate posture, etc., may lead to waking up with neck pain. 2. Falling pillow: usually due to sleeping process pillow height is not suitable or sleeping posture is not appropriate, resulting in the neck muscles for a long time excessive bending or stretching, resulting in neck muscle sprain, may lead to wake up neck pain. It may also be accompanied by limited neck movement and other manifestations. 3. Cervical spondylosis: If there is a history of cervical spondylosis, especially the presence of cervical disc herniation or cervical spondylolisthesis. When sleeping, due to improper sleeping posture, compression of local nerves, may cause a wake-up neck pain, may also be accompanied by headache, hand numbness and other manifestations. Wake up with neck pain, may also be related to other factors, to rule out physiological factors, it is recommended to consult a doctor in a timely manner, to clarify the cause, to give targeted treatment.