The absence of esophageal wall thickening is normal and generally suggests the absence of gastrointestinal disorders such as reflux esophagitis, smooth muscle tumors of the esophageal wall, and esophageal cancer. The specific situation depends on the individual’s physical condition. In some patients, the thickening of esophageal wall is caused by inflammation, such as chronic esophagitis and reflux esophagitis, during which the mucosa becomes congested and edematous, and the lumen narrows; if the esophagus is hyperplastic and elevated, it is considered to be smooth muscle tumor of the esophagus; if the esophagus is abnormally hyperplastic and infringes on the smooth muscle, it is considered to be esophageal cancer. However, the wall of the esophagus is not thick indicating that no signs of esophagitis, esophageal cancer and other diseases have been found. However, the specifics should be considered in the context of the individual’s physical condition. If symptoms such as acid reflux occur or are accompanied by other systemic symptoms, one should go to the hospital promptly to have the cause clarified and then give targeted treatment.