TTE-1, thyroid transcription factor 1, is a nuclear protein with a molecular weight of 38-40 KD and is localized in the nucleus. It is the basic material for thyroid differentiation and thyroglobulin secretion regulation, and can promote the transportation of thyroid peroxidase, iodine and sodium. Mainly distributed in thyroid follicular epithelial cells, parathyroid cells, respiratory epithelial cells and other cell tissues.
1. Highly expressed in thyroid cancer and lung cancer, used in the differential diagnosis of small cell carcinoma of the lung, adenocarcinoma of the lung, and metastatic lung adenocarcinoma. It is also expressed in chordoma-like glioma of the third ventricle, pituitary cell tumor and adenopituitary spindle cell tumor.
2. The expression of TTF-1 in lung cancer, such as 100% of thyroid follicular carcinomas, 96% of papillary thyroid carcinomas, 95% of lung neuroendocrine tumors, 90% of medullary thyroid carcinomas, 75% of lung adenocarcinomas, and 63% of non-small cell carcinomas.
3. Among them, the intensity of TTF-1 positive expression in non-small cell carcinoma of the lung is negatively correlated with the prognosis of the patients and can be used as an independent prognostic target. Lung adenocarcinoma has high sensitivity and specificity, and after excluding the possibility of thyroid cancer, positive TTF-1 expression is largely suggestive of lung adenocarcinoma.
It is recommended to make judgment under the guidance of professional doctors according to the specific conditions of patients, and a single index cannot make a definite diagnosis.