Neocoron is generally referred to as novel coronavirus pneumonia, and gargling with salt water is usually not a defense against novel coronavirus pneumonia. New coronavirus pneumonia is an acute contagious pneumonia, which is mainly transmitted through respiratory droplets, close contact, etc. It can also be transmitted through aerosols, and a small number of patients are infected by contact with viral contaminants. Therefore, gargling with salt water does not protect against the new coronavirus pneumonia, and people with recent mouth ulcers may feel discomfort with the pain of gargling with salt water. In order to effectively protect against the new coronavirus pneumonia, people should seek medical attention as soon as possible to get vaccinated against the new coronavirus, so as to encourage the body to produce protective antibodies. When going out, people should wear masks and avoid close contact with others. People should also exercise properly, eat nutritious food, and maintain a happy body and mind. It is recommended to pay attention to oral care, brush teeth and gargle regularly to help maintain oral hygiene. Pay attention to opening windows and ventilation, and do sterilization at home on a regular basis. Tip: The terms “new coronary pneumonia and new coronary virus pneumonia” mentioned in this article were renamed to “new coronary virus infection” on December 26, 2022, as announced by the National Health Commission.