The average red blood cell volume of 60.4 belongs to low, which may be caused by iron deficiency anemia, thalassemia, leukemia and so on, and the specific treatment should be implemented according to different causes. 1. Iron deficiency anemia: usually due to insufficient intake of iron, the body has less iron, there is no way to synthesize hemoglobin, so the hemoglobin in each red blood cell is reduced, and the corresponding volume of red blood cells will be reduced. You can take ferrous sulfate tablets and iron dextrose tablets to replenish iron under medical advice. 2. Thalassemia: it is a hereditary disease, which is mainly caused by the quantity and quality of hemoglobin in red blood cells. You need to go to the regular hospital for blood transfusion treatment in time, and take the method of bone marrow transplantation if necessary. 3. Leukemia: a large number of leukemia cells proliferate unrestrictedly in bone marrow and other hematopoietic tissues and enter the peripheral blood, inhibiting the production of red blood cells and platelets, and then the average red blood cell volume will be low. It is recommended to use chemotherapy to achieve the therapeutic effect under doctor’s supervision. If the above symptoms occur, please consult a doctor immediately, after clarifying the cause of the disease, timely treatment, so as to avoid delaying the disease.