Omeprazole can be used in the treatment of atrophic gastritis, but omeprazole belongs to the inhibition of gastric acid secretion of drugs, in the treatment of atrophic gastritis must be used with caution, so as not to exacerbate the atrophy of the gastric mucosa. For the treatment of atrophic gastritis, generally to gastric mucosal protective agent treatment, unless clearly have Helicobacter pylori infection caused by atrophic gastritis, this time need to be given formal quadruple therapy, eradication of Helicobacter pylori treatment, such as the use of omeprazole plus bismuth, and then add two antibiotics. In addition, if the patient with atrophic gastritis, the main clinical symptoms are mainly abdominal pain, can also be appropriate to use drugs to inhibit gastric acid secretion, such as omeprazole. But for other clinical symptoms, it is recommended to be cautious, and it is best to treat mainly with gastric mucosal protectants. And for patients with atrophic gastritis must be closely followed up for review, check the electronic gastroscopy plus pathological examination, in order to clarify the development of gastric mucosal atrophic lesions, if there is a severe atypical hyperplasia, then you need to carry out preventive surgical treatment.