Calcification of the head of the pancreas is some dense tissue that occurs inside the pancreas. There are two main types of calcification: physiologic calcification and pathologic calcification. Physiologic calcification usually requires no treatment and should be kept under observation for changes. Pathological calcification is caused by inflammatory damage to the pancreatic tissue and can be treated with oral analgesic, anti-inflammatory and acid-suppressing drugs. 1. Physiologic calcification: If the patient’s pancreatic neuroendocrine function is normal, digestive function is normal, and there are no special symptoms, there is no need for intervention. 2. Pathological calcification: it is caused by acute pancreatitis or chronic pancreatitis, both of which will carry out the absorption of inflammation through wrapping and calcification. This leads to calcium salt precipitation and formation of such calcified lesions. The damage to pancreatic enzymes by gastric acid is usually reduced by analgesia with non-steroidal anti-inflammatory drugs such as celecoxib, or by taking some pancreatic enzyme preparations such as pancreatic enzyme tablets and multi-enzyme tablets in combination with omeprazole. In addition to oral medication, patients with pancreatic head calcification can be treated by surgery if necessary. The above needs to be carried out under the guidance of physicians to avoid further aggravation of the condition.