The XE variant strain of the new coronavirus is characterized by its rapid transmission, high infectivity, and sequelae. The XE mutant strain is a recombinant mixture of the two strains of Omicron BA.1 and BA.2. It spreads faster than other new coronavirus strains and has a shorter infection time. The infectiousness is reflected in the smaller distance of transmission, and the population may be infected after a little contact, so the number of infected people is higher. Sequelae of infection with the XE mutant strain of the new coronavirus include taste and smell disorders, gastrointestinal symptoms, cardiovascular and cerebrovascular diseases, and pulmonary fibrosis. During the epidemic, we should take good protective measures, disinfect and ventilate frequently, and if you feel unwell, it is recommended that you consult a doctor in time to avoid delaying your condition.