Pemphigus is an autoimmune disease whose etiology is unclear, mainly due to the presence of autoantibodies in the patient’s blood against the inter-epidermal cellular components, which results in the appearance of flaccid blisters and maculopapular blisters on the skin or mucous membranes. The immune system of a normal organism can recognize itself and non-self components, and generate an immune response to non-self antigens, while being immune-tolerant or non-responsive to self-antigens, keeping the organism in a stable state. If the patient’s immune system is disturbed and breaks the body’s own stability, autoimmune diseases will occur. Pemphigus antibodies exist in patients with pemphigus, and antigen recognition by the body can lead to the loss of intercellular adhesion, resulting in the loosening of the spiny cells, which leads to the formation of blisters. It is also important to note that some medications carry the risk of inducing pemphigus, such as D-penicillin, piroxicam, captopril, and rifampicin, which contain a hydrosulfur moiety. People with pemphigus should be cautious of consuming foods rich in hydrosulfur groups such as garlic, which may aggravate the lesions. If you suffer from pemphigus, you should actively cooperate with your doctor for treatment.