It is possible to have only one seizure, but epilepsy with only one seizure would not be diagnosed as epilepsy, but as epileptic seizures or called epileptiform seizures. There are normal people who do not have a family history of epilepsy or a history of brain injury, excluding various diseases such as traumatic brain injury, encephalitis, tumors, cerebrovascular disease, etc. It is possible for a patient to have one seizure under specific external triggers. For example, patients with chronic sleep deprivation, continuous overwork, high mental stress, and consumption of large amounts of excitatory substances, such as alcohol, tea, and coffee, may have one seizure, but afterwards, as long as there are no similar triggers, the patient may not have another similar seizure. For this condition, epilepsy is not clinically diagnosed and oral antiepileptic drugs are not required for treatment. However, the prerequisite is a cranial MRI to rule out organic brain disease and an EEG in the normal range.