The gallbladder has the function of concentrating, storing, and excreting bile, so after cholecystectomy, some people may experience clinical symptoms of dyspepsia and steatorrhea, especially after eating fatty foods. The majority of the population is able to play a similar physiological role due to the compensatory dilation of the bile ducts and therefore does not experience significant discomfort. Due to the compensatory widening of the bile ducts, there is also a possible increased risk of secondary bile duct stones. However, there is no evidence-based basis to support the current claim of increased incidence of colorectal cancer after cholecystectomy. A small number of patients may also develop post-cholecystectomy syndrome after cholecystectomy, mainly manifested as abdominal pain, high fever, chills, jaundice and so on. This is mainly due to injury to the bile ducts during surgery, excessive length of the leftover cystic ducts, abnormal sphincter function and abnormal peristalsis of the gastroduodenum, and requires active symptomatic management and, if necessary, reoperation.