Antipyretic and analgesic drugs have some gastrointestinal irritation and it is recommended to take such drugs after meals. Children and adolescents should avoid taking aspirin in case of viral infections and can opt for acetaminophen. Avoid drinking alcohol after taking cold medication as it may cause liver damage. Most cold and flu medications are over-the-counter. It is not advisable to use antipyretic and analgesic medications on your own for a long time, and if you do not get better after taking them at home for a few days, you should go to the hospital promptly. Common antipyretic and analgesic drugs include acetaminophen and ibuprofen, cold medicine compound ingredients generally with acetaminophen, ibuprofen for single-use.