Dry mouth and thirst in the middle of the night are usually related to Yin deficiency, dampness and heat. It can be treated with medicines such as Liuwei Di Huang Pill and Huo Xiang Qing Stomach Granules after identification. 1. Yin deficiency: Patients with Yin deficiency will have insufficient fluid in the body, which cannot nourish the mouth, and they will have dry mouth and thirst in the middle of the night. This can be treated with Liou Wei Di Huang Pill to nourish yin and tonify the kidneys. It is important to note that it is not advisable to take cold and flu medicines during the medication. 2. Dampness and heat: Dampness and heat can easily block the qi, resulting in fluid not being able to be carried up to the mouth, so there may be a dry mouth and thirst in the middle of the night, in addition to excessive sweating, sticky mouth and other manifestations. We can use Huo Xiang Qing stomach particles to clear heat and dampness treatment. It should be noted that pregnant women should not take. Although there is no clear adverse reaction to the above drugs, but it is recommended to take medication under the guidance of a Chinese medicine practitioner, often in the middle of the night, dry mouth and thirst should be timely medical treatment, do not take medication, so as not to delay the condition or adverse reactions.