Burning sensation in the stomach is mostly caused by chronic gastritis, gastroesophageal reflux disease, peptic ulcer, etc. It is commonly treated with medications, such as proton pump inhibitors (omeprazole). 1. Chronic gastritis: patients with chronic gastritis will have heartburn pain, bloating and other manifestations. It can be treated with gastric stimulants, such as domperidone and mosapride, and proton pump inhibitors, such as omeprazole and lansoprazole. If the patient has high-grade epithelial sarcomatoid changes in the stomach, gastroscopic mucosal stripping and gastroscopic mucosal resection can be taken. 2. Gastroesophageal Reflux Disease (GERD): GERD will present with burning sensation in the upper abdomen, epigastric pain and other manifestations. Proton pump inhibitors such as omeprazole can be used, as well as mucosal protective agents, such as aluminum thioglycollate and magnesium aluminum carbonate. For those with severe gastroesophageal reflux, laparoscopic fundoplication and endoscopic anti-reflux surgery can be taken. 3. Peptic ulcer: burning sensation in the middle and upper abdomen, pain in the middle and upper abdomen and other manifestations may occur. Proton pump inhibitors such as omeprazole and lansoprazole can be given. For chronic gastritis caused by Helicobacter pylori infection, it is necessary to take quadruple therapy as prescribed by the doctor, such as omeprazole, bismuth potassium citrate, amoxicillin, clarithromycin and so on. In addition to the above causes of burning sensation in the stomach, there are drinking alcohol, coffee, stimulating food or drugs and other factors, it is recommended that timely medical treatment, need to follow the doctor’s advice to choose the appropriate measures to treat the cause of the disease, to avoid self-medication, delay the condition.