Midnight throat tickling cough can be caused by a variety of factors, if it is transient, may be due to inhalation of irritants; if it is persistent, should be considered cough cough variant asthma, chronic obstructive pulmonary disease (COPD), tuberculosis, lung cancer and so on. 1. Cough variant asthma: Cough variant asthma can have symptoms of paroxysmal cough. Coughing at night can be observed to start coughing at the point in time there is no cause of the occurrence of coughing allergens, if so, should reduce contact with allergens, etc., can go to the hospital for further examination to confirm. 2. Chronic Obstructive Pulmonary Disease (COPD): COPD is most common in middle-aged and elderly people with a history of smoking. Most of them cough in the morning, but there are also night cough. 3. Tuberculosis: Tuberculosis also has the symptom of cough, and may be accompanied by wasting, chest pain, hemoptysis and so on. If diagnosed, standardized anti-tuberculosis treatment should be started as soon as possible. 4. Lung cancer: Lung cancer can also be manifested as cough, but it is mostly accompanied by systemic symptoms. It should be noted that if it is transient, it may be the normal physiological reaction caused by inhalation of irritants, and persistent midnight cough with tickling throat should be examined in local hospitals for clear diagnosis and treated by professional doctors.