Multi-system atrophy is a neurodegenerative disease, mainly related to genetic, environmental and other factors, can cause urinary frequency, urinary urgency and other symptoms, patients need to comply with the medical advice of medication, if necessary, surgical treatment. Multi-system atrophy is a group of adult-onset, sporadic neurodegenerative diseases, commonly seen in men aged 50 to 60. The etiology of the disease is not clear, but it may be related to genetic factors, environmental factors and so on. Among them, environmental factors are reflected in the exposure to heavy metals and agricultural work. It is currently believed that the pathogenesis of multiple system atrophy may be related to the degenerative loss of neuronal myelin sheath, the discovery of inclusion bodies in oligodendrocytes, and the degenerative death of neurons. The first symptom of patients with multiple system atrophy is autonomic dysfunction, and patients often present with urinary frequency, urgency, and incontinence. And some patients will also have symptoms similar to Parkinson’s disease such as motor retardation, limb tremor, but levodopa treatment is ineffective, as well as symptoms of cerebellar ataxia such as unsteady walking, muscle weakness, and slurred speech. It is recommended that patients with multiple system atrophy be treated with medication under the guidance of a doctor, and should not use medication indiscriminately. Daily attention to maintain physical and mental pleasure, should also ensure adequate sleep, avoid overwork.