Hand, foot and mouth disease can be caused by the coxsackie virus and other viruses. The skin is particularly itchy and medications such as ribavirin and glycerine lotion can be used, while scratching of the rash should be avoided. Hand, foot and mouth disease is a common childhood infection, mostly seen in children under 5 years old. Symptomatic treatment is mainly given, and medications such as ribavirin and interferon alpha can be used for early treatment. Itchy skin is a rare symptom and can be relieved with medications such as glycerite. At the same time, it is necessary to pay attention to the child to cut the nails short, try to avoid scratching the rash, clothing, bedding to keep clean and dry. Most HFMD patients have a good prognosis, but a small number of severe cases may be directly life-threatening. It is recommended that the patient go to the hospital in a timely manner and use medication under the direction of the doctor.