The sympathetic nerve of patients who stay up late for a long time is in an excited state, so it will increase the oxygen consumption of the heart muscle, which will increase the blood supply and oxygen supply to the heart, so it will increase the preload and afterload of the heart. In addition, for patients who stay up late for a long time, the heart belongs to the fatigue work state, and does not get timely rest and recuperation, then patients usually belong to the situation of rapid heart rate, and in the long run will also cause the impact on heart function due to rapid heart rate. Long-term stay up late for the cardiovascular endothelial cells have certain harmful and stimulating effects, such as long-term stay up late, and the habit of smoking, the stimulation of cardiovascular endothelial cells will be greater, so long-term stay up late on the heart has a very negative impact.