The effect of multivitamin supplementation on stroke risk is unclear. Recently, the journal published a study to examine the association between multivitamin use and the risk of stroke and its subtype-related deaths. A study of more than 70,000 Japanese men and women who were free of cardiovascular disease and cancer at baseline was conducted and followed up to December 31, 2009. Participants’ lifestyles, including multivitamin use, were obtained through a self-administered questionnaire. At a mean follow-up of 19.1 years, the study identified 2087 stroke-related deaths, including 1148 ischemic strokes and 877 hemorrhagic strokes. After adjusting for potential confounders, multivitamin use remained associated with a reduced risk of overall stroke death, but this relationship was at the margin of statistical significance and was primarily associated with ischemic stroke and not with hemorrhagic stroke. In a subgroup analysis, for those who consumed fruits and vegetables <3 times/day, multivitamin consumption was associated with a decreased risk of overall stroke death. This association appeared to be more pronounced in long-term users than in occasional users. Similar results were found for ischemic stroke. The study showed that in a Japanese population with a low intake of fruits and vegetables, multivitamin use, especially frequent use, was associated with a decreased risk of death from overall stroke and ischemic stroke.