It is not recommended to squeeze out a mature wheal with a cotton swab, as squeezing a mature wheal with abscess formation can lead to spreading of the abscess to form cellulitis or even intracranial infection. A granuloma is a localized infection of the eyelid caused by pyogenic bacteria such as Staphylococcus aureus. Since the eyelid tissue is loose and in the danger triangle, and the veins have no valves, squeezing the abscess after maturity can lead to spreading of the infection, and it may even develop into cellulitis or even intracranial infection caused by blood reflux. The correct treatment for mature granuloma is to go to the hospital for incision surgery under strict aseptic sterilization to drain the abscess of granuloma completely. After the operation, the patient should be treated with anti-inflammatory and anti-infection therapy such as tobramycin and dexamethasone ophthalmic ointment, and the patient should be treated with physical therapy such as hot compress and massage to promote the recovery of the wound. It is recommended to be careful with granuloma that has matured abscess formation, do not squeeze or pick, need to go to professional ophthalmology for surgical incision and drainage.