Blackheads, pimples, and closed mouths, or acne, can be removed through medication, physical therapy, and general measures of conditioning. 1. Medication: Patients suffering from acne can follow the doctor’s instructions to use retinoids such as retinoic acid cream, which can play a role in dissolving pimples and anti-inflammatory effects, as well as erythromycin ointment, fusidic acid cream and other antibiotic ointment. In addition, serious acne patients can also follow the doctor’s instructions to use isotretinoin capsules and other retinoids, which can inhibit abnormal keratinization and the formation of blackheads, and oral doxycycline, minocycline and other anti-inflammatory treatment. 2. Physical therapy: Patients suffering from acne can also take physical therapy, mainly photodynamic therapy, chemical peeling, laser therapy and other treatment modalities. 3. General measures: Patients with acne should pay attention to their living habits, should not use irritating toiletries, patients should pay attention to the cleanliness and dryness of the face, but should not be over-cleaned. Patients are advised to avoid sun exposure when going out. Patients suffering from acne should consult a doctor in time and follow the doctor’s instructions for treatment.