Negative closed antibody is not normal, closed antibody negative easy to cause miscarriage, closed antibody exists in the normal serum of pregnant women, only closed antibody positive indicates that the body has closed antibody. The body has closed antibody can prevent the pregnant woman’s body immune system on the fetus, can prevent miscarriage, stillbirth and other conditions, if the body lacks closed antibody will cause repeated miscarriage. So you need to go to the hospital for examination, if there is a closed antibody negative, you need to use reasonable medication under the guidance of the doctor, you need to inject the white blood cells extracted from the body of the spouse, the specific medication you need to follow the doctor’s instructions. It is best not to get pregnant during the treatment period to avoid miscarriage again, only after complete cure can you get pregnant. Under normal circumstances, 2-3 months after treatment with medication to return to normal, 6 months before you can get pregnant, so as not to affect the development of the baby too early pregnancy.