The difference between redness between the fissure and liver palms are pathogenesis, clinical manifestations and so on. 1. Causes: one of the redness between the fishes may be caused by liver palms, while others may be caused by high blood pressure, heart disease, thrombocytopenia, anemia, diabetes, asthma, and even over-exertion, etc. Liver palms are due to the inactivation of estrogens, which is commonly seen in cirrhosis of the liver, and are sometimes accompanied by spider naevi. 2. Clinical manifestations: Liver palms usually show pink spots or plaques, which turn pale after pressure is applied, and then turn red when the pressure is lifted; the color of the palm is normal, and the redness of the small fissure does not change color after pressure is applied. To summarize, the latter is one of the former situation, the emergence of timely medical treatment.