Whether chemotherapy is needed for stage II colon cancer should depend on the patient’s specific situation. If the patient has high-risk factors for recurrence, then chemotherapy is needed; if the patient does not have high-risk factors for recurrence, then follow-up consultation is needed, and if abnormalities are found during the follow-up consultation, chemotherapy may still be needed. Stage I colon cancer tends to be confined to the colonic mucosa, stage II colon cancer foci tend to invade the plasma membrane layer without lymph node metastasis, and stage III and above colon cancers tend to be accompanied by lymph node metastasis and metastasis to distant organs. Only stage I and II colon cancer can undergo radical colon cancer surgery, and whether chemotherapy is needed after surgery should depend on the patient’s specific situation. Chemotherapy is needed if the patient has high-risk factors for recurrence, such as low differentiation of tumor tissue, nerve invasion or vascular cancer embolism, preoperative bowel obstruction or bowel perforation, or the number of lymph nodes resected in the surgery is less than 12, infiltration around the nerves, perforation of the tumor as well as margins adjacent to the tumor tissues or the margins of the tumor are not sure whether they are positive or the margins are definitely positive, and so on. Some patients can be followed up and if abnormalities occur during follow-up, chemotherapy is still required. If stage II colon cancer is diagnosed, follow your doctor’s instructions.