Eradication of H. pylori requires a second eradication treatment after the first failure. The second eradication treatment requires switching to other antibiotics and increasing patient compliance. Patients who fail H. pylori treatment tend to have two conditions, mainly drug resistance and poor compliance. Due to the widespread use of antibiotics, H. pylori is resistant to many drugs, with the highest rates of resistance to metronidazole and clarithromycin, up to 90% to metronidazole, with a relatively large variation from place to place in the rate of resistance to furazolidone, and an overall low rate of resistance to amoxicillin and tetracycline, which can be tried. In addition, the patient’s compliance is poor, there are cases of random discontinuation, intermittent dosing, not completing the course of treatment on time, and arbitrarily reducing the dose.