Whether folliculitis with pustules (large pouches) can heal on its own is related to the degree of infection; mild cases can subside, while severe cases often require medication to recover. The hair follicle is an acute, subacute, chronic purulent, non-purulent inflammatory disease that occurs in the hair follicle, and is relatively common clinically. The pus growth with pustules is mainly caused by staphylococcus, because scratching and scratching the skin causes staphylococcal infection. Non-purulent, mostly red papules, are usually associated with occupations, such as long-term exposure to coal tar, long-term use of corticosteroids and hormones, and frequent work in wet environments. Red papules are also prone to develop into pustules when adversely irritated. The pustules usually contain white or yellow fluid, crust over when they rupture, and may be accompanied by pus and blood when they rupture. For mild bacterial folliculitis, after the bacteria invade the body, the body’s natural immune system automatically recognizes and releases, chemokines as well as inflammatory factors, which are involved in the clearance of the pathogen. When the pathogen is cleared, the activated cells begin to apoptosis under the body’s own metabolism and the inflammatory response subsides, at which point the pustules caused by mild bacterial folliculitis can heal spontaneously, a process that takes about 5-7 days. For severe bacterial folliculitis, the pustules are difficult to subside on their own, and the ruptured infection is usually accompanied by systemic complications such as rising body temperature, nausea, vomiting, and aching limbs, etc. It is recommended to seek medical attention and actively treat with sensitive antibiotic drugs to avoid further aggravation or bacteremia.