The possible causes of chest pain after staying up all night include neurosis, angina pectoris, pleurisy, gastrointestinal disorders, intercostal neuralgia, and so on. Diseases are different, the nature of the pain may be different, should be timely to the hospital, further examination to clarify the cause of the disease, formal treatment. 1. Neurosis: usually manifested as pins and needles pain in the chest, which can be improved within a few seconds, with no clear triggers for the attack, without affecting the activities, and with no abnormalities in chest CT and cardiac ultrasound, electrocardiogram and other examinations. You can take ibuprofen orally for pain relief. 2. Angina pectoris: angina pectoris occurs as stuffy pain, distension, burning pain, etc., preferably occurring in the area behind the sternum and in the anterior region of the heart, and usually improves within a few minutes, which may be accompanied by chest tightness, sweating, etc., and requires coronary angiography and other tests, and medication or surgery depending on the severity of the disease. 3. Pleurisy: the pain caused by pleural inflammation is usually hidden, deep breathing or aggravated after activity, chest CT examination can be clarified, if necessary, need to apply antibiotics to fight infection and pain relief treatment. 4. Digestive tract diseases: esophagitis, esophageal hiatal hernia, gastroesophageal reflux and other diseases may occur behind the sternum pain, chest pain in the late night, usually related to diet, can be clarified through gastroscopy. 5. Intercostal neuralgia: mostly caused by varicella-herpes zoster virus infection, thoracic spine lesions, trauma, etc. The pain is obvious in the semi-circumferential band area radiating along the intercostal space to the front chest or abdomen, and deep inhalation, coughing or sneezing can induce or aggravate the pain.